Protein sorting, targeting and trafficking in photoreceptor cells
نویسندگان
چکیده
منابع مشابه
Nuclear trafficking of photoreceptor protein crx: the targeting sequence and pathologic implications.
PURPOSE To identify the targeting sequence controlling the nuclear transport of the photoreceptor-specific transcription factor cone-rod homeobox (Crx) protein and to address the question of whether disease-causing Crx mutations disrupt the nuclear trafficking of the Crx protein. METHODS A series of cDNA fragments encoding Crx protein with deleted C termini were generated from mouse Crx cDNA ...
متن کاملMyelin Biogenesis: Sorting out Protein Trafficking
Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport and cytoskeletal dynamics. Recent studies indicate that soluble neuronal signals may control the surface expression of proteolipid protein, a process that involves reduced endocytosis and/or increased transport carrier recruitment from an intracellular pool.
متن کاملSorting out Receptor Trafficking
in membrane or luminal/extracellular domains of these proteins, while somatodendritic signals, like basolateral signals, are found in cytoplasmic domains. However, Establishing and maintaining the proper spatial distribu-there are also contradictions to this " analogous mem-tion of integral membrane proteins is a functional neces-brane domain " hypothesis. Previous structure–function sity of al...
متن کاملTargeting HSP90 and monoclonal protein trafficking modulates the unfolded protein response, chaperone regulation and apoptosis in myeloma cells
Multiple myeloma is characterized by the production of substantial quantities of monoclonal protein. We have previously demonstrated that select inhibitors of the isoprenoid biosynthetic pathway (IBP) induce apoptosis of myeloma cells via inhibition of Rab geranylgeranylation, leading to disruption of monoclonal protein trafficking and induction of the unfolded protein response (UPR) pathway. H...
متن کاملThe GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells
Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the ion channels transient receptor potential (TRP) and TRP-like (TRPL) and generates the visual response. The signaling proteins are located in a plasma membrane compartment called rhabdomere. The ma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Progress in Retinal and Eye Research
سال: 2013
ISSN: 1350-9462
DOI: 10.1016/j.preteyeres.2013.03.002